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PHARMACEUTICAL COMPOSITION FOR TREATMENT OF BONE DISEASES, WHICH CONTAINS PROTEIN COMPRISING BONE MORPHOGENETIC PROTEIN RECEPTOR 1B (BMPR1B) EXTRACELLULAR DOMAIN OR MUTANT THEREOF
PHARMACEUTICAL COMPOSITION FOR TREATMENT OF BONE DISEASES, WHICH CONTAINS PROTEIN COMPRISING BONE MORPHOGENETIC PROTEIN RECEPTOR 1B (BMPR1B) EXTRACELLULAR DOMAIN OR MUTANT THEREOF
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机译:用于治疗包含骨形态发生蛋白受体1B(BMPR1B)的细胞外区或其突变蛋白的骨疾病的药物组合物
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摘要
Disclosed is a pharmaceutical composition for the treatment of bone diseases, which contains, as an active ingredient: a protein that comprises a bone morphogenetic protein receptor 1B (BMPR1B) extracellular domain derived from a mammal or a mutant of the BMPR1B extracellular domain, said mutant having 85% or higher sequence identity with the amino acid sequence of the domain and having an effect of increasing the bone mass, bone density and/or bone strength; or a vector comprising a nucleic acid encoding the protein. Examples of the bone diseases may include osteoporosis, osteoarthritis, rheumatoid arthritis, bone diseases associated with malignant tumors or the like, and various bone diseases or disorders associated with the aforementioned diseases.
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