PRMT1 AND PRMT6 FOR TARGET GENES OF CANCER THERAPY AND DIAGNOSIS

摘要

Objective methods for diagnosing a predisposition to developing cancer, particularly bladder cancer, gastric cancer, colorectal cancer, breast cancer, esophageal cancer, lung cancer, lymphoma, pancreatic cancer and testicular cancer, are described herein. In one embodiment, the diagnostic method involves determining an expression level of PRMT1 or PRMT6 gene. The present invention further provides methods of screening for therapeutic agents useful in the treatment of PRMT1 or PRMT6 associated diseases, such as a cancer, e.g., bladder cancer, diffuse-type gastric cancer, breast cancer, esophageal cancer, NSCLC, SCLC, lymphoma, pancreatic cancer, testicular cancer, cervical cancer, osteosarcoma, prostate cancer and CML. The present invention further provides methods of inhibiting the cell growth and treating or alleviating symptoms of PRMT1 or PRMT6 associated diseases. The present invention also features products, including double-stranded molecules and vectors encoding thereof as well as to compositions containing them.