DIARYLMETHYLAMIDE DERIVATIVE HAVING ANTAGONISTIC ACTIVITY ON MELANIN-CONCENTRATING HORMONE RECEPTOR

摘要

[Problem];To provide a melanin-concentrating hormone receptor antagonist useful as a pharmaceutical agent for central diseases, circulatory diseases, and metabolic diseases.;[Means for Resolution];Provided is a diarylmethylamide derivative represented by formula (I):Wherein R^1a, R^1b, R^2a, R^2b, R^3a, and R^3b independently represent a hydrogen atom or the like, R⁴ represents a hydrogen atom, C_1-6 alkyl, or the like, R⁵ represents a hydrogen atom or the like, Z represents C_1-6 alkyl or the like, or R⁴ and Z together form a 4- to 6-membered nitrogen-containing hetero ring, Y₁ represents H or the like, Y₂ represents H, or Y₁ and Y₂ together form - O-CH₂-, W represents C, SO, or the like, Ar₁ represents 6-membered aryl or the like, Ar₂ represents 6-membered aryl or the like, and ring A represents a benzene ring, a pyridine ring, or the like.