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Design, Synthesis, and Structure-Activity Relationships of Thieno2, 3-bpyridin-4-one Derivatives as a Novel Class of Potent, Orally Active, Non-Peptide Luteinizing Hormone-Releasing Hormone Receptor Antagonists

机译：Thieno 2,3-B吡啶-4-一衍生物作为一种新型效力，口服活性，非肽丁黄激素激素释放激素受体拮抗剂的设计，合成和结构 - 活性关系

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1. Design, synthesis, and structure-activity relationships of thieno[2,3-b]pyridin-4-one derivatives as a novel class of potent, orally active, non-peptide luteinizing hormone-releasing hormone receptor antagonists [J] . Imada T, Cho N, Imaeda T, Journal of Medicinal Chemistry . 2006,第13期

机译：Thieno [2,3-b] pyridin-4-one衍生物作为一类新型的，有效的，口服活性的，非肽类黄体生成激素的激素释放拮抗剂的设计，合成及构效关系
2. Discovery of a thieno(2,3-d)pyrimidine-2,4-dione bearing a p-methoxyureidophenyl moiety at the 6-position: a highly potent and orally bioavailable non-peptide antagonist for the human luteinizing hormone-releasing hormone receptor. [J] . Sasaki S, Cho N, Nara Y, Journal of Medicinal Chemistry . 2003,第1期

机译：发现在6-位带有p-甲氧基脲基苯基部分的thieno（2,3-d）pyrimidine-2,4-dione：人类促黄体生成激素释放激素受体的一种高效且可口服生物利用的非肽拮抗剂。
3. Discovery of novel and potent orally active calcium-sensing receptor antagonists that stimulate pulselike parathyroid hormone secretion: Synthesis and structure-activity relationships of tetrahydropyrazolopyrimidine derivatives [J] . Yoshida M., Mori A., Kotani E., Journal of Medicinal Chemistry . 2011,第5期

机译：发现新型有效的口服活性钙敏感受体拮抗剂，刺激脉冲状甲状旁腺激素分泌：四氢吡唑并嘧啶衍生物的合成与构效关系
4. Rational Design of Peptidomimetics for Class B GPCRs: Potent Non-Peptide GLP-1 Receptor Agonists [C] . Jung-Mo Ann, Sun-Young Han, Eunice Murage American Peptide Symposium . 2009

机译：B类GPCR的肽肌瘤的理性设计：有效的非肽GLP-1受体激动剂
5. Synthesis of new glutamate receptor probes: I. Total synthesis of dysiherbaine, a potent glutamate receptor excitotoxin; II. Design and synthesis of dysiherbaine analogues; III. Synthesis and structure-activity relationships of substituted benzothiadiazides and their role as AMPA receptor modulators. [D] . Phillips, Dean Paul. 2001

机译：新型谷氨酸受体探针的合成：I. dysiherbaine的全合成，一种有效的谷氨酸受体兴奋性毒素；二。 dysiherbaine类似物的设计和合成；三，取代的苯并噻二叠氮化物的合成及其构效关系及其作为AMPA受体调节剂的作用。
6. Inhibition of growth of human mammary tumor cells by potent antagonists of luteinizing hormone-releasing hormone. [O] . Y Sharoni, E Bosin, A Miinster, 1989

机译：黄体生成激素释放激素的强效拮抗剂可抑制人乳腺肿瘤细胞的生长。
7. Design of 2, 5-Dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo1, 5-apyrimidine (NBI 30775/R121919) and Structure-Activity Relationships of a Series of Potent and Orally Active Corticotropin-Releasing Factor Receptor Antagonists [O] . -1

机译：设计为2,5-二甲基-3-（6-二甲基-4-甲基吡啶-3-基）-7-双溴吡啶吡唑唑1,5-甲嘧啶（NBI 30775 / R121919）和一系列有效和口头活性的结构 - 活性关系Corticotropin发布因子受体拮抗剂

Design, Synthesis, and Structure-Activity Relationships of Thieno2, 3-bpyridin-4-one Derivatives as a Novel Class of Potent, Orally Active, Non-Peptide Luteinizing Hormone-Releasing Hormone Receptor Antagonists

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