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METHOD OF TREATING PNEUMOCONIOSIS WITH OLIGODEOXYNUCLEOTIDES

机译:寡聚寡核苷酸治疗肺尘埃沉着病的方法

摘要

Methods are disclosed for treating, preventing or reducing the risk of developing occupational lung diseases, such as pneumoconiosis. In several embodiments, the methods include administering a therapeutically effective amount of the suppressive ODN to a subject having or at risk of developing a pneumoconiosis, thereby treating or inhibiting the pneumoconiosis. In several examples, thee subject can have or be at risk of developing silicosis, asbestosis or berryliosis. The method can include selecting a subject exposed to, or at risk of exposure to, inorganic particles, including, but not limited to silica, asbestos, berrylium, coal dust, or bauxite.
机译:公开了用于治疗,预防或减少发展职业性肺部疾病例如尘肺的风险的方法。在一些实施方案中,所述方法包括将治疗有效量的抑制性ODN施用给患有尘肺病或有发生尘肺病的风险的受试者,从而治疗或抑制尘肺病。在几个例子中,所述受试者可以患有矽肺病,石棉沉着症或贝氏菌病或具有患矽肺病,石棉沉着症或贝氏菌病的风险。该方法可以包括选择暴露于或可能暴露于无机颗粒的受试者,所述无机颗粒包括但不限于二氧化硅,石棉,浆果,煤粉或铝土矿。

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