A continuous process of preparing 5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, an intermediate for synthesizing non-ionic X-ray contrast agents

摘要

This invention relates to an improved method for the synthesis of 5-amino-N,N'- bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (Compound B), an intermediate in the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to a continuous process of the iodination reaction of 5-amino-N,N'-bis(2,3-dihydroxypropyl-isophthalamide (ABA) or ABA-HCl followed by the purification of Compound B.