ANTI-TUBERCULOSIS PREPARATION BASED ON AN INCLUSION COMPLEX OF CYCLODEXTRIN WITH RIFAMPICIN AND A METHOD FOR THE PREPARATION THEREOF

摘要

An anti-tuberculosis preparation based on an inclusion complex of cyclodextrin with rifampicin and a method for the preparation thereof. The invention relates to the pharmaceutical industry and may be utilized in medical institutions for the treatment of tuberculosis. Using the claimed ratio of components, the preparation, which consists of an inclusion complex of cyclodextrin with rifampicin in a molar ratio of 1:1, and granulated isoniazid with a pH-sensitive polymer of auxiliary substances - sweetener, a disintegrator, a hepatoprotector, an antioxidant and a mixture of lubricating substances - calcium or magnesium stearate and aerosil, makes it possible to minimize the first stage of absorption of the preparation while maintaining the bio-availability of the rifampicin with low toxicity (LD₅₀ 5000 mg/kg), and it can be used not only for adults, but also for children.