Method and device to obtain physiological parameters and detect clinical or subclinical abnormalities during a kidney substitution treatment

摘要

The invention relates to devices and methods for detecting clinical and subclinical abnormalities during a kidney substitution treatment, by measuring continuously a kidney substitution treatment dialysate. The detection of the abnormalities is achieved by fitting the time dependency of a first set of measurements to a physiological model, extracting the physiologically relevant parameters, and comparing further measurements performed in real-time to the corresponding model predictions. Detection of a deviation from the expected behaviour triggers an alarm and/or measures to confirm or correct the abnormality detection. Estimation the rebound effects taking place after the kidney substitution treatment is also contemplated.