首页>
外国专利>
METHOD OF REDUCING MOTILITY IN BACTERIA BY OVEREXPRESSION OF A GENE OF OI-1 GENOMIC ISLAND
METHOD OF REDUCING MOTILITY IN BACTERIA BY OVEREXPRESSION OF A GENE OF OI-1 GENOMIC ISLAND
展开▼
机译:OI-1基因岛基因过表达降低细菌运动能力的方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
Z0021 was identified as a gene within the O-Island 1 (OI-1) genomic island of verocyto-toxin-producing E. coli O157:H7. The gene negatively regulates swimming motility and this decreased motility is the result of a reduction in surface expression of flagella. Overexpression of Z0021 suppresses the motility and surface expression of flagella in E. coli O157:H7, as well as in other Enterobacteriaceae including E. coli K12 and S. typhimurium SL1344. Disclosed is a method of reducing motility in bacterium by increasing the level of the peptide having the amino acid sequence as set forth in SEQ ID No:2 which is encoded by the Z0021 gene having the nucleotide sequence as set forth in SEQ ID No: 1.
展开▼
机译:Z0021被鉴定为在产卵细胞毒素的大肠杆菌O157:H7的O-Island 1(OI-1)基因组岛中的一个基因。该基因负调节游泳运动,这种运动降低是鞭毛表面表达降低的结果。 Z0021的过表达抑制了大肠杆菌O157:H7以及包括大肠杆菌K12和鼠伤寒沙门氏菌SL1344在内的其他肠杆菌科中鞭毛的活力和表面表达。本发明公开了一种通过增加具有SEQ ID No:2所示氨基酸序列的肽的水平来降低细菌运动力的方法,该肽由具有SEQ ID No:1所示核苷酸序列的Z0021基因编码。 。
展开▼