Use of Triglyceride Oils Containing Gamma-Linolenic Acid Residues and Linoleic Acid Residues for the Treatment of a Neurodegenerative Disease

摘要

A triglyceride oil is provided containing both γ-linolenic acid and linoleic acid residues as triglyceride ester for the treatment of neurodegenerative disease wherein the oil is administered at a dose sufficient to elevate or maintain TGF-β1 levels in the patient to or at a therapeutic level such as to produce a TGF-β1/TNF-α ratio of at least 0.5 in blood of a patient, after 18 months of daily dosing characterised in that the oil is obtained from a fungus of Mucor species; the ratio of γ-linolenic acid to linoleic acid residues at the sn-2 position of the triglyceride is at least 0.8; the amount of γ-linolenic acid residues at the sn-2 position is at least 18%, the dose is sufficient to administer at least 1 gram of γ-linolenic acid residues, as residues in the sn-2 position, excluding other γ-linolenic acid content of the oil.