HETERO-MULTIVALENT BINDING AGENTS FOR MEMBERS OF THE TGF SUPERFAMILY

摘要

The invention provides hetero-multivalent ligand binging agents (traps) for members of the TGF-beta superfamily, as well as methods for making and using such constructs. In an embodiment of the invention there is provided a hetero-multivalent binding agent with affinity for a member of the TGF-beta superfamily. The agent comprises the general structure I: (bd1-linker1)k-[{bd1-linker2-bd2-linker3f-}n-(bd3)m-(linker4-bd4)d]h, where bd1, bd2, bd3 and bd4 are polypeptide binding domains having an affinity for different sites on the same member or for different members of the TGF-beta superfamily; at least two of bd1, bd2, bd3, and bd4 are different from each other.