MODULATING NEURONAL PLASTICITY AND TREATMENT OF NEURONAL LOSS BY MODULATING WNT7A OR WNT7B MODULATION

摘要

The present invention relates to a method of treating or preventing a disease characterized by a loss or imbalance of neuronal connections, wherein said disease characterized by a loss or imbalance of neuronal connections is selected from a group of diseases consisting of age-related loss of neuronal performance and/or connections, psychiatric disorders, neurodegenerative diseases characterized by loss of neuronal connections, learning deficiency, and senile dementia, of modulating neuronal activity and/or neuronal plasticity, of optimizing repair after brain injury, to modulate learning, and/or to modulate cognitive capabilities, in a subject and/or, of preventing loss of neuronal connections and/or to increase neuronal connections in said subject, by modulating Wnt-signaling, which method is characterized by the fact that the subject is in puberty or post-puberty, wherein puberty or post-puberty means that the neuronal circuits of said subject have already undergone developmental synapse elimination and critical periods which take place prior to puberty.