PYRAZOLIDINE COMPOUND FOR CONTROLLING ACTIVITY OF Z-DNA BINDING PROTEIN

摘要

A novel pyrazolidine compound is provided to inhibit the biological function of a Z-DNA bonding protein by being specifically coupled to the Z-DNA bonding protein, thereby being used as an anti-viral agent. A pharmaceutical composition for controlling activity of a Z-DNA bonding protein comprises a therapeutically effective amount of a pyrazolidine compound represented by a formula(1) or a pharmaceutically acceptable salt and a pharmaceutical carrier or an excipient. In the formula(1), R1 is C6-20 aryl; R2 is C5-20 aryl or C5-20 heterocycle including O or N; each X and Y is independently C or N. A pharmaceutical composition for treating or preventing fox virus or vaccinia virus comprises the compound of the formula(1) or the pharmaceutically acceptable salt thereof and the pharmaceutically acceptable carrier or the excipient.