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A radioimmunoconjugate for diagnosis and treatment of cancer or metastasis and development of cancer or cancer metastasis inhibitor using thereof
A radioimmunoconjugate for diagnosis and treatment of cancer or metastasis and development of cancer or cancer metastasis inhibitor using thereof
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机译:用于诊断和治疗癌症或转移的放射免疫缀合物以及使用其的癌症或癌症转移抑制剂的开发
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摘要
Disclosed are a radio-immunoconjugate for diagnosis and treatment of cancer or metastasis and development of metastasis inhibitory formulations using the same. More particularly, the present invention provides a radio-immunoconjugate as material indicating a metastatic cancer that has antibody marked with any lanthanum radionuclide and/or gamma, beta or alpha ray emitting radioisotopes targeting a vascular endothelial growth factor receptor (VEGFR). Such a radio-immunoconjugate is advantageous in that it maintains structural stability of a protein and immune activity thereof and is effectively adsorbed to the surface of vascular endothelial cells, thereby being useful as a pre-metastatic site detection factor. When the radio-immunoconjugate is administered to an animal model with a cancer, the radio-immunoconjugate is accumulated in cancer tissues, and therefore, is useful for development of radioactive metastasis inhibitory formulations.
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