HYALURONIC COMPOUND FOR PROVIDING HYALURONIC ACID-BASED SOFT TISSUE FILLER WITH IMPROVED PERSISTENCE, AND A PREPARATION METHOD AND USE THEREOF

摘要

PURPOSE: A hyaluronic acid-based soft tissue filler with a hyaluronic compound is provided to ensure long biodegradation rate, to generate collagen although filler is biodegraded and to reduce needs to again inject filler to the applied soft tissue.;CONSTITUTION: A hyaluronic compound with a structure of chemical formula 1 comprises the steps of: preparing pullulan-retinoic acid of following chemical formula 4 through an ester bond between pullulan with a structure of chemical formula 2 and retinoic acids with a structure of chemical formula 3; and cross-linking a methanol group and a methanol group of a hyaluronic acid through ether bond by reacting a pullulan-retinoic acid assembly of chemical formula 4, hyaluronic acid of chemical formula 5, and 1,4-butanediol diglycidyl ether as a cross-linking agent.;COPYRIGHT KIPO 2011