VECTOR WHICH CONTAINS AND EXPRESSES BMP-2 AND HSV-TK SUICIDE GENE AND A STEM CELL THERAPEUTIC AGENT OF SELF-REGULATION USING THE SAME

摘要

PURPOSE: A vector which contains and expresses BMP-2 and HSV-tK suicide gene and a stem cell therapeutic agent of self-regulation in which the vector is introduced are provided to remove cancer occurrence possibility and to reduce in vivo immunodepression.;CONSTITUTION: A DNA cassette comprises a nucleic acid sequence of BMP and nucleotide acid of suicide gene between transcription/translation initiator sequence. The BMP has a nucleic acid sequence of human BMP-2 of sequence number 1. The suicide gene is HSV-tk having a nucleic acid sequence of sequence number 3. An expression vector has the DNA cassette. A stem cell therapeutic agent of self-regulation contains mesenchymal stem cells as an active ingredient, obtained by proliferation of recombinant adenovirus-infected stem cells. The therapeutic agent is used for treating bone diseases.;COPYRIGHT KIPO 2011