首页>
外国专利>
BIFUNCTIONAL BIS-CINCHONA ALKALOID THIOUREA ORGANIC CHIRAL CATALYST COMOUND AND A METHOD FOR PREPARING A CHIRAL AMINO ACID
BIFUNCTIONAL BIS-CINCHONA ALKALOID THIOUREA ORGANIC CHIRAL CATALYST COMOUND AND A METHOD FOR PREPARING A CHIRAL AMINO ACID
展开▼
机译:双功能双喜子草碱硫脲有机手性催化剂化合物及手性氨基酸的制备方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
PURPOSE: A bifunctional bis-cinchona alkaloid thiourea organic chiral catalyst compound and a method for preparing the same are provided to obtain (R)-type N-acyl amino acid ester of highly optical purity.;CONSTITUTION: A bifunctional bis-cinchona alkaloid thiourea organic chiral catalyst compound is denoted by chemical formula 1. In chemical formula 1, R is ethyl group or -CH=CH_2. The bifunctional organic chiral catalyst is obtained by reacting amine with carbothio diimidazole. The amine is obtained from cinchona alkaloid by epimerization. A chiral N-acyl amino acid ester is obtained by reacting N-acyl amino acid, racemic azlactone, (S)-azlactone or (R)-azlactone with neucleophile under the presence of bifunctional chiral organic catalyst. The neucleophile is alcohol or thiol.;COPYRIGHT KIPO 2011
展开▼