CONTROLLED DRUG RELEASE SYSTEM BY FLUORINATION/OXYFLUORINATION BASED ON PH-RESPONSIVE HYDROGEL

摘要

PURPOSE: a kind of rate preparing pH-sensitive type hydrogel for drug conveying is according to being provided to the pH concentration of control response hydrogel and the drug of solubility. ;CONSTITUTION: a kind of to prepare the step of pH-sensitive type pharmaceutical hydrogel includes: a kind of mixing, polyvinyl alcohol, pH sensitivity vinyl monomers, crosslinking agent and soluble drug obtain hydrogel precursor solution; A kind of polymerization procedure and cross-linked gel liquid solution, are dried to obtain pH-sensitive type hydrogel; It is fluorinated with the surface of amendment step pH-sensitive type hydrogel by fluorination or oxygen. The soluble drug is Coomassie brilliant blue. ;The 2011 of copyright KIPO submissions