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ORAL PHARMACEUTICLA COMPOSITION CONTAINGING LUTEIN USING SELF-MICRO EMULSION SYSTEM
ORAL PHARMACEUTICLA COMPOSITION CONTAINGING LUTEIN USING SELF-MICRO EMULSION SYSTEM
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机译:自微乳体系的包含蛋白的口腔药物组合物
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摘要
PURPOSE: A pharmaceutical composition for oral administration of lutein using a self emulsifying drug delivery system is provided to enhance solubility of lutein and to effectively deliver lutein in vivo and in vitro. CONSTITUTION: A pharmaceutical composition for oral administration of lutein contains a mixture of oil phase/surfactant/co-surfactant and lutein. The mixture contains 50-70 volume% of surfactant, 5-25 volume% of co-surfactant, and 10-50 volume% of oil. The surfactant is selectd from the group consisting of Labrosol, Capryol PGMC, polyoxylated castor oil, tween, and span. The co-surfactant is selected from the group consisting of Transcutol-PH, Lutrol-E400, Peceol, Lauroglycol 90, and Capryol 90. The oil phase is selected from the group consisting of Phosal 35, Phosal 53 MCT, Peceol, and Labrafac CC.
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机译:目的:提供用于使用自乳化药物递送系统口服施用叶黄素的药物组合物,以增强叶黄素的溶解性并有效地在体内和体外递送叶黄素。组成:用于口服叶黄素的药物组合物包含油相/表面活性剂/助表面活性剂和叶黄素的混合物。该混合物包含50-70体积%的表面活性剂,5-25体积%的助表面活性剂和10-50体积%的油。表面活性剂选自Labrosol,Capryol PGMC,聚氧化蓖麻油,吐温和跨度。辅助表面活性剂选自Transcutol-PH,Lutrol-E400,Peceol,Lauroglycol 90和Capryol90。油相选自Phosal 35,Phosal 53 MCT,Peceol和Labrafac CC 。
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