ZEBRAFISH MODEL FOR INFLAMMATORY DISEASE AND SCREENING METHOD OF ANTI-INFLAMMATORY AGENT USING THE SAME

摘要

PURPOSE: A zebra fish model for inflammatory diseases and a method for screening an anti-inflammatory agent using the same are provided to screen effective anti-inflammatory agent without side effects. CONSTITUTION: A method for screening an anti-inflammatory agent using zebra fish model comprises: a step of treating one selected from the group consisting of lipopolysaccharides, oxidized low-density lipoprotein, and saccharification apolipoprotein to the zebra fish; and a step of administering a candidate drug to the zebra fish and evaluating the development and apoptosis of an embryo. The inflammatory diseases are inflammatory dermatitis, glomerulus nephritis, inflammatory bowel disease, inflammatory collagen vascular disease, osteoarthritis, inflammatory eye disease, IgA nephropathy, rheumatoid arthritis, post-vaccinal encephalomyelitis, and diabetes.