FUSION ANTIGEN WHICH IS USED IN MANUFACTURING DENDRITIC CELL VACCIEN FOR IMMUNOTHERAPY

摘要

PURPOSE: A fusion antigen and a method for manufacturing a mature dendritic cell vaccine for immunotherapy using the same are provided to improve efficiency. ;CONSTITUTION: A fusion antigen used in manufacturing dendritic cell vaccine for immunotherapy contains PTD-MUC1 fusion protein containing MUC1(mucin antigen 1) fused to protein transduction domain(PTD) or PTD-Ag85A fusion protein. The fusion antigen is PTD-MUC1-Ag85A or PTD-Ag85A-MUC1. A method for manufacturing the dendritic cell vaccine comprises: a step of preparing immature dendritic cells; and a step of culturing the cells with the fusion antigen for maturing the cells. A pharmaceutical composition for anticancer immunotherapy contains pharmaceutically effective amount of the dendritic cell vaccine and pharmaceutically acceptable carrier.;COPYRIGHT KIPO 2011