PREPARATION AND CHARACTERIZATION OF PEG-PLA(PLGA) MICELLES FOR SOLUBILIZATION OF ROSIGLITAZONE

摘要

PURPOSE: A drug-encapsulated biocompatible polymer micelle is provided to maximize encapsulation of drugs and to improve safety in a solution of the micelle. CONSTITUTION: A biocompatible polymer micelle contains amphiphilic diblock copolymer, hydrotrophic formulation, and insoluble drug. A method for manufacturing the micelle comprises: a step of mixing amphiphilic diblock copolymers and insoluble drug under the presence of a solvent to prepare a gel; a step of dispersing the gel in an aqueous phase and adding hydrotrophic formulation to prepare a micelle solution; and a step of freeze-drying the micelle solution. The insoluble drug is pioglitazone, rosiglitazone, or mixture thereof. A pharmaceutical composition for treating or preventing diabetes contains the micelles as an active ingredient.