首页> 外国专利> A COMPOSITION FOR TREATING DISEASE CAUSED BY NEURONAL INSULT COMPRISING SCHWANN CELL-LIKE CELLS THAT SECRETING HIGH AMOUNT OF GROWTH FACTORS AS ACTIVE INGREDIENTS

A COMPOSITION FOR TREATING DISEASE CAUSED BY NEURONAL INSULT COMPRISING SCHWANN CELL-LIKE CELLS THAT SECRETING HIGH AMOUNT OF GROWTH FACTORS AS ACTIVE INGREDIENTS

机译:一种用于治疗神经疾病的组合物,该组合物包括分泌大量生长因子作为活性成分的施万氏细胞样细胞

摘要

The present invention relates to a therapeutic agent for nerve injury cells containing Schwann cells as an active ingredient. Specifically, Schwann cells differentiated from human mesenchymal stem cells of the present invention are hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF). Overexpressing HGF and VEGF through the secretion of nerve cells and spinal cord tissue sections of the damaged spinal cord of the nerve fibers and cells to increase the growth and suppression of cell death to act directly as a growth factor As confirmed, the differentiated Schwann cells of the present invention are a composition for delivery of HGF or VEGF in a subject for treatment or improvement of a subject having a neurological disorder and a cell therapeutic agent derived from autologous tissue without genetic manipulation for treating a nervous system injury. It can be used easily.
机译:本发明涉及含有雪旺氏细胞作为有效成分的神经损伤细胞治疗剂。具体地,从本发明的人间充质干细胞分化出来的雪旺氏细胞是肝细胞生长因子(HGF)和血管内皮生长因子(VEGF)。通过神经纤维和受损脊髓的神经细胞和脊髓组织切片的分泌过表达HGF和VEGF,从而增加生长并抑制细胞死亡,直接充当生长因子。本发明是一种用于在受试者中递送HGF或VEGF的组合物,用于治疗或改善患有神经系统疾病的受试者和衍生自自体组织的细胞治疗剂,而无需进行遗传操作来治疗神经系统损伤。它可以很容易地使用。

著录项

  • 公开/公告号KR20110104684A

    专利类型

  • 公开/公告日2011-09-23

    原文格式PDF

  • 申请/专利权人 SNU R&DB FOUNDATION;

    申请/专利号KR20100023715

  • 发明设计人 CHANG MI SOOK;

    申请日2010-03-17

  • 分类号A61K35/28;A61P25;C12N5/079;C12N5/02;

  • 国家 KR

  • 入库时间 2022-08-21 17:51:05

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