Acid addition salts of thiol compounds and processes for preparing the same

摘要

The present invention is method of acid addition salts of synthetic intermediates that is, a thiol compound of antibiotics and the cover page nemgye provide a novel acid addition salt of a thiol compound obtained from the production process . Since the manufacturing method of the acid addition salt of a thiol compound that is a synthetic intermediate of the cover page nemgye antibiotics according to the present invention may be prepared by acid addition salt of a thiol compound with high yield and purity without the need to perform the column chromatography , the mass production of industrial scale is suitable. In addition , the acid addition salt is by having a solid form , it is easy to handle , easy to long term storage at the production site . In addition , it is possible to form the azetidine ring without performing the silylation reaction , the reaction steps can largely be shortened .