A composition comprising the compound isolated from the extract of Rubiae Radix for preventing and treating inflammatory disease

摘要

The present invention relates to a composition containing a compound isolated from Cheoncho Geun extract as an active ingredient, specifically, the compound isolated from Cheoncho Geun extract is LPS-induced NO production, p- in RAW264.7 cells, which are mouse macrophages Not only reduces protein expression of IkBα, iNOS and COX-2, but also significantly reduces the expression content of proinflammatory cytokines such as mRNA expression of iNOS, COX-2, TNF-α, IL-6 and IL-1β. By confirming, the composition can be usefully used as a pharmaceutical composition or health functional food for the prevention and treatment of inflammatory diseases.;NO production, p-IkBα, iNOS, pro-inflammatory cytokines, inflammatory diseases