ETHERAL DERIVATIVES AS DUAL 5-NT2A AND D3 RECEPTOR MODULATORS

摘要

1. Compounds of the general formula I:! ! where A is aryl or 5-12 membered heteroaryl, which are optionally substituted! halogen atom! cyano! C1-6 alkyl optionally substituted with cyano or C1-6 alkoxy! C1-6 alkoxy! -S (O) 2-C1-6alkyl; ! R1 is C1-6 alkyl optionally substituted! one or more than one halogen atom, C1-6 alkoxy or aryl, possibly substituted by a halogen atom,! or is C3-10-cycloalkyl optionally substituted with one or more than one Ra,! or is a 5-12 membered heterocycloalkyl optionally substituted with one or more than one Ra,! or represents aryl, possibly substituted by one or more than one Ra,! or is a 5-12 membered heteroaryl optionally substituted with one or more than one Ra,! or is —NRbRc, where Rb is H or C 1-6 alkyl and! where Rc is H, C1-6-alkyl or aryl, optionally substituted with one or more than one Ra,! where Ra is selected from! halogen atom! S (O) 2-C1-6-alkyl,! cyano! oxo! C1-6 alkyl, possibly substituted with aryl, which is substituted by a halogen atom,! C1-6-haloalkyl,! C1-6-haloalkoxy,! C1-6 alkoxy optionally substituted with a 5-6 membered heteroaryl, optionally substituted with C1-6 alkyl! -NH (CO) -C1-6-alkyl,! 5-6 membered heterocycloalkyl or! 5-6 membered heteroaryl optionally substituted with C1-6 alkyl or oxo; ! R2 is H or OH; ! and their pharmaceutically acceptable salts. ! 2. The compounds of formula I according to claim 1, wherein A is aryl, optionally substituted with one or more halogen atoms, cyano or C1-6 alkyl. substituted cyano, or A is a 5- or 6-membered heteroaryl. ! 3. Compounds of the formula