ALLOCATED POPULATIONS OF MYELINE CELLS AND METHODS OF TREATMENT USING SUCH POPULATIONS

摘要

1. An isolated population of myeloid cells, most of which expresses the CD44 antigen, CD11b antigen, and hypoxia-induced factor 1α (HIF-1α). ! 2. The selected population of myeloid cells according to claim 1, where the cell population is obtained using a method comprising isolating bone marrow from a mammal and positive selection of bone marrow cells capable of immune interaction with an antibody selected from the group consisting of anti-CD44 antibody, antibodies against CD11b and combinations thereof. ! 3. The selected population of bone marrow myeloid cells according to claim 1, wherein the cells also express CD204, CD114, CD33 and CD115. ! 4. The selected population of myeloid cells according to claim 1, where at least about 75% of the population cells express CD44. ! 5. The selected population of myeloid bone marrow cells according to claim 1, where at least about 90% of the population cells express CD44. ! 6. The selected population of myeloid cells according to claim 1, where the cells are murine. ! 7. The selected population of myeloid cells according to claim 6, where the cell population essentially does not contain cells expressing TER-119. ! 8. The selected population of myeloid bone marrow cells according to claim 1, where the cells are human. ! 9. A method of restoring and stabilizing the functional vasculature in hypoxic tissue of the retina, comprising contacting the hypoxic tissue of the retina with an effective number of cells from an isolated population of myeloid cells according to claim 1. ! 10. A method for stimulating physiological intrathoracic vascularization of hypoxic retinal tissue while suppressing the formation of abnormal preretinal cells