Pyridopyrimidinone compounds useful in the treatment of diseases or conditions mediated by sodium channels

摘要

1. The compound of formula (I) !! where n is 1, 2, 3 or 4; ! each R1 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, halogen, haloalkyl, haloalkenyl, haloalkynyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkylalkyl, aryl, aryl, aryl, aryl, aryl, aryl , heteroarylalkyl, heteroarylalkenyl, heteroarylalkynyl, -R6-CN, -R6-NO2, -R6-OR5, -R6-N (R4) R5, -R6-S- (O) pR4, -R6-C (O) R4, R6-C (S) R4, -R6-C (R4) 2C (O) R5, -R6-C (O) OR4, -R6-OC (O) R4, -R6-C (S) OR4, -R6 -C (O) N (R4) R5, -R6-C (S) N (R4) R5, -R6-N (R5) C (O) R4, -R6-N (R5) C (S) R4, -R6-N (R5) C (O) OR4, -R6-N (R5) C (S) O R4, -R6-N (R5) C (O) N (R4) R5, -R6-N (R5) C (S) N (R4) R5, -R6-N (R5) S (O) tR4, - R6-N (R5) S (O) tN (R4) R5, -R6-S (O) tN (R4) R5, -R6-N (R5) C (= NR5) N (R4) R5 and -R6- N (R5) C (N = C (R4) R5) N (R4) R5, where each p is independently 0, 1 or 2, and each t is independently 1 or 2; ! or two adjacent R1 groups, together with the carbon atoms to which they are directly attached, form a fused ring selected from optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heterocyclyl or optionally substituted heteroaryl, and the other R1, if present, have the above meanings; ! R2 is hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl, aryl, aralkyl, aralkenyl, aralkynyl, heterocyclyl, heterocyclylaryl, heterocyclylaryl, heterocyclyl-aryl, OR5 or -R6-N (R4) R5; ! R3 represents hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, hydroxyalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkene