IDENTIFICATION OF HUMAN T2R RECEPTORS, BINDING WITH Bitter COMPOUNDS, GIVING A HOT TASTE TO COMPOSITIONS, AND THEIR APPLICATION IN ANALYSIS FOR DETERMINING COMPOUNDS, INHIBITION INHIBIBILITY

摘要

1. The compound of structural Formula (I) indicated below! ! or its salt, hydrate, solvate or N-oxide, where! Ar1 represents a five- or six-membered aryl, heteroaryl or cycloalkyl ring; ! m is 0, 1, 2 or 3; ! R1 is SO2; C is O; C = S; or C = NOR4; ! X is selected from the group consisting of hydrogen, halogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, acyl, substituted acyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, substituted heteroaryl, NO, heteroaryl , OR6, S (O) bR6, NR6R7, CONR6R7, CO2R6, NR6CO2R7, NR6CONR7R8, NR6CSNR7R8, NR6C (= NH) NR7R8, SO2NR5R6, NR5SO2R6, NR5SO2NR6R7) OR (P5) OR6) and P (O) (R5) (OR6); ! each R1 ′ is independently selected from the group consisting of hydrogen, halogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, acyl, substituted acyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, CN, NO2, OR6, S (O) bR6, NR6R7, CONR6R7, CO2R6, NR6CO2R7, NR6CONR7R8, NR6CSNR7R8, NR6C (= NH) NR7R8, SO2NR5R6, NR5SO2R6, NR5SO6 (OR) OR OR5) (OR6) and P (O) (R5) (OR6); ! or, alternatively, X and / or at least one R1 ′ together with the atoms to which they are attached form an aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl or substituted cycloheteroalkyl ring, where this ring is, optionally fused to another aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl or substituted cycloheteroalkyl ring; ! R