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METHOD FOR SYNTHESIS OF TRITIUM-LABELLED 2-PHENYL SUBSTITUTED ISOQUINOLINE DERIVATIVES
METHOD FOR SYNTHESIS OF TRITIUM-LABELLED 2-PHENYL SUBSTITUTED ISOQUINOLINE DERIVATIVES
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机译:RIT标记的2-苯酚取代的异喹啉衍生物的合成方法
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摘要
FIELD: chemistry.;SUBSTANCE: present invention relates to a method for synthesis of tritium-labelled 2-phenyl substituted isoquinoline derivatives of general formula: , according to which isoquinoline undergoes a reaction for direct phenylation of a nitrogen atom with nucleogenic free phenyl cations. The source of pheny cations is a hexane solution twice titrated with benzene and the process is carried out in a closed system in the presence of a strong stabilising anion of potassium tetrafluoroborate.;EFFECT: novel single-step method for synthesis of tritium-labelled 2-phenyl substituted isoquinoline derivatives.;1 cl, 1 ex
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机译:synthesis标记的2-苯基取代的异喹啉衍生物的合成方法技术领域本发明涉及一种general标记的2-苯基取代的异喹啉衍生物的合成方法,该衍生物的通式为:<图像文件=“ 00000001.GIF” he =“ 39” imgContent =“ undefined” imgFormat = “ GIF” wi =“ 53” />,根据该异喹啉经历了用于使氮原子与成核游离苯基阳离子直接苯基化的反应。苯阳离子的来源是用苯两次滴定的己烷溶液,该过程在密闭系统中于强稳定的四氟硼酸钾阴离子存在下进行。效果:新颖的一步法合成synthesis标记的2 -苯基取代的异喹啉衍生物。; 1 cl,1 ex
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