METHOD OF PRODUCING ORAL PREPARATION OF PROINSULIN C-PEPTIDE

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: invention refers to pharmacology and medicine, and represents a method of producing an oral preparation of proinsulin C-peptide of activated polyethylene glycol differing by the fact that polyethylene glycol is activated by ionising radiation in an acidic medium with calcium and/or zinc cations added to final concentration 5-10 mM, and then mixed with proinsulin C-peptide, polyethylene glycol is characterised by molar mass 0.4-40 kDa and concentration 1.0-50.0%, in relation of proinsulin C-peptide: polyethylene glycol equal to 1:(1-500) to final concentration of proinsulin C-peptide in mixture 1-10 mg/ml.;EFFECT: invention provides higher therapeutic activity in oral administration with respect to diabetic complications.;4 cl, 3 ex,1 tbl, 2 dwg