SUBSTITUTED IMIDAZOLES, PHARMACEUTICAL COMPOSITION, METHOD OF TREATING DISEASE, ASSOCIATED WITH, AT LEAST, KSP ACTIVITY AND METHOD OF KSP INHIBITION

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: claimed invention relates to novel substituted imidazole compounds of formula I where values of radicals are given in description, as well as to their based on them pharmaceutical compositions.;EFFECT: formula I compounds, as well as their salts, esters and compositions based on them possess ability to inhibit protein of kinesin spindle (KSP) and can be used for treatment of cancer diseases.;40 cl, 15 ex, 3 tbl