VACCINE STRAIN OF B/60/MALAYSIA/04/898 INFLUENZA VIRUS FOR PREPARING LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN

摘要

FIELD: medicine.;SUBSTANCE: B/60/Malaysia/04/898 strain actively replicates in growing chicken embryos at optimum temperature 32-33°C. It is characterised by thermal sensitivity and cold adaptation. A reassortant has inherited the genes coding surface virus antigens - hemagglutinin (HA) and neuraminidase (NA) from an epidemic parent virus. The other six genes code internal non-glycosylated proteins from an attenuation donor. The B/60/Malaysia/04/898 strain is areactogenic for adults and children in intranasal introduction.;EFFECT: invention can be used in practical health services for preventing seasonal influenza incidence in adults and children by a live influenza intranasal vaccine of the strain of said influenza virus.;4 tbl