VACCINE STRAIN OF A/17/BRISBANE/07/1 (H3N2) INFLUENZA VIRUS FOR PREPARING LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN

摘要

FIELD: medicine.;SUBSTANCE: A/17/Brisbane/07/1 (H3N2) strain replicates actively in growing chicken embryos at optimum temperature 32°C. A reassortant has inherited the genes coding surface virus antigens - hemagglutinin (HA) and neuraminidase (NA) from an epidemic parent virus. The other six genes coding internal non-glycosylated proteins have been inherited from an attenuation donor. The A/17/Brisbane/07/1 (H3N2) strain is areactogenic for adults and children in intranasal introduction. The invention can be used in practical health services for preventing seasonal influenza incidence in adults and children by a live influenza intranasal vaccine of the A/17/Brisbane/07/1 (H3N2) strain.;EFFECT: strain is characterised by thermal sensitivity and cold adaptation.;1 dwg, 3 tbl