LENTIVIRAL REPORTER VECTOR SYSTEM FOR MEASURING ACTIVITY OF KEY TRANSCRIPTIONAL FACTORS REFLECTING FUNCTIONAL STATUS OF SIGNALLING PATHWAYS OF CELL

摘要

FIELD: medicine.;SUBSTANCE: invention can be used for determining a functional status of primary signalling pathways of a cell. Substance of the invention are lentiviral reporter vector structures containing reporter markers. The invention allows predicting the tumour sensitivity to therapeutic exposures and developing an individual therapeutic approach.;EFFECT: creating the lentiviral reporter vector structure optimal for determining the activity of transcriptional factors reflecting the functional status of signalling pathways of the cell.;6 cl, 16 dwg