METHOD OF PRODUCING D-GLUCOSE LABELLED WITH CARBON ISOTOPE IN POSITION 1

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to a method of producing D-glucose which is labelled with carbon isotopes ¹³C or ¹⁴C in position 1, involving condensation of D-arabinose with labelled nitromethane, taken in equimolar ratio, in dimethylsulphoxide in the presence of a base, followed by benzene extraction of excess dimethylsulphoxide, freeze-drying from benzene, cooling the reaction mixture of 1-desoxy-1-nitroalditol salts to liquid nitrogen temperature, adding water, followed by slow thawing while stirring and decomposition of 1-desoxy-1-nitroalditol salts contained in the obtained aqueous solution, and extraction of D-glucose via chromatography. Said method increases output and improves the process.;EFFECT: obtaining products used in medicine as isotopic diagnostic agents, as well as in scientific research and other fields.;3 cl, 4 ex