PEPTIDE DERIVED FROM A PROTEIN OF THE FAMILY OF AQUAPORINS AND COSMETIC AND / OR PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

摘要

Aquaporin peptides (I) are new. Aquaporin peptides of formula (I) are new. R 1-(AA) n-X 1-X 2-X 3-Pro-X 4-X 5-X 6-(AA) p-R 2(I) X 1Ser or no amino acid; X 2Met, Leu or no amino acid; X 3Asn, Gln or no amino acid; X 4Ala or Gly; X 5Arg, Lys or no amino acid; X 6Ser, Asp or no amino acid; AA : any amino acid; n, p : 0-4; R 1H, acetyl, benzoyl, tosyl or benzyloxycarbonyl; R 2OH, 1-20C alkoxy, NH 2, NHY or NYY; Y : 1-4C alkyl. ACTIVITY : Dermatological. MECHANISM OF ACTION : Osmotic shock protectant. Human keratinocyctes were cultured in the presence of 3% Asn Pro Ala Arg for 24 hours before being subjected to osmotic shock with 250 mM sorbitol for 24 hours. Cell viability was increased by 12% over controls.