STUDY ON THE ANTI-TUMOR EFFICACY INDUCED BY HEAT SHOCK PROTEIN 70-PEPTIDE COMPLEXES DERIVED FROM TUMOR CELLS

傅庆国; 张玮; 孟凡东; 郭仁宣; 姚振宇

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STUDY ON THE ANTI-TUMOR EFFICACY INDUCED BY HEAT SHOCK PROTEIN 70-PEPTIDE COMPLEXES DERIVED FROM TUMOR CELLS

机译：肿瘤细胞衍生的热激蛋白70肽复合物诱导的抗肿瘤作用研究

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机译：Objective. To study the efficacy and explore the mechanism of the anti-tumor immunity elicited by heat shock protein 70-peptide complexes (HSP70-PC) derived from tumor cells. Methods. Cells culture, flow cytometric analysis, affinity chromatography for protein purification, SDS-PAGE, Western-blotting and animal experiment were used. Results. HSP70-PC immunization rendered protective effect to both naive and tumorl-bearing mice. All of the naive mice obtained complete resistance to Hcaf cell attack; 40% of the tumor-bearing mice survived for over 90 days, whereas the mice of control group died within 2 weeks (P<0.01). CD8+ subset of T lymphocytes in the peripheral blood of immunized mice increased by 12% . Conclusion. HSP70-PC induces anti-tumor immunity via activation of cytotoxic T lymphocytes (CTLs), and it possesses strong tumor vaccine effect. Our research adds more evidence to support the clinical use of HSP70-PC to fight human cancers.

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来源
《中国医学科学杂志（英文版）》 |2002年第3期|153-156|共4页
作者
傅庆国; 张玮; 孟凡东; 郭仁宣; 姚振宇;
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作者单位

The Second General Surgery Department the First Affiliated Hospital of China Medical University Shenyang 110001;

Shenyang Feng Yi Tumor Research Institute Senyang 110005;

Immunology Department of China Medical University Shenyang 110001;

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原文格式 PDF
正文语种 chi
中图分类基础医学;
关键词
neoplasm; heat shock protein 70-peptide complexes; tumor vaccine;

机译：肿瘤;热激蛋白70肽复合物;肿瘤疫苗;

STUDY ON THE ANTI-TUMOR EFFICACY INDUCED BY HEAT SHOCK PROTEIN 70-PEPTIDE COMPLEXES DERIVED FROM TUMOR CELLS

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