TARGETED DELIVERY OF BOTULINUM TOXIN FOR TREATMENT AND PREVENTION OF TRIGEMINAL AUTONOMIC CEPHALALGIA, MIGRAINE AND VASCULAR CONDITION

摘要

PROBLEM TO BE SOLVED: To treat and prevent migraine and other headaches associated with vascular disorders.SOLUTION: Botulinum toxin, among other presynaptic neurotoxins is used for the treatment and prevention of migraine and other headaches associated with vascular disorders. The presynaptic neurotoxins are delivered locally, targeting the nerve endings of the trigeminal nerve, the occipital nerve and the intranasal terminals of the parasympathetic fibers originating in the pterygopalatine ganglion. The administration preferably targets the extracranial nerve endings of the trigeminal nerve in the temporal area, the extracranial occipital nerve endings in the occipital area, and the intranasal terminals of the trigeminal nerve and parasympathetic fibers originating in the pterygopalatine ganglion. The delivery is carried out by way of injection or topically.