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METHOD OF SCREENING DRUG CANDIDATE COMPOUND TO Gs-COUPLED RECEPTOR
METHOD OF SCREENING DRUG CANDIDATE COMPOUND TO Gs-COUPLED RECEPTOR
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机译:筛选候选候选化合物至Gs偶联受体的方法
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摘要
PROBLEM TO BE SOLVED: To provide a method of screening a drug candidate compound with respect to a Gs-coupled receptor without causing desensitization while activating the Gs-coupled receptor.SOLUTION: This method can efficiently screen a compound without causing desensitization while activating the Gs-coupled receptor using a partial agonist activity with respect to the Gs-coupled receptor as an indicator. The receptor is one receptor selected from a group comprising: a 1 adrenaline receptor; a 2 adrenaline receptor; a 3 adrenaline receptor; and a GLP-1 receptor.
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