PRODUCTION METHOD OF OPTICALLY ACTIVE CYCLOHEXENE DERIVATIVE, OPTICALLY ACTIVE CYCLOHEXENE DERIVATIVE, AND PRODUCTION METHOD OF OPTICALLY ACTIVE CYCLOHEXADIENE DERIVATIVE AND OPTICALLY ACTIVE CYCLOHEXADIENE DERIVATIVE USING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide a method for easily producing an optically active cyclohexene derivative with high yield and high purity by a simple operation, the derivative having a fluorine-containing hydrocarbon as a substituent in a cyclohexene skeleton and being useful as a synthetic intermediate for medicines, agricultural chemicals, electronic materials or the like.;SOLUTION: An optically active cyclohexene derivative having a fluorine-containing hydrocarbon as a substituent in a cyclohexene skeleton is obtained through an asymmetric Diels-Alder reaction of olefins (1) having a fluorine-containing hydrocarbon and dienes (2) coexistent with an asymmetric source such as an optically active oxazaborolidine derivative in the presence of a Lewis acid such as tin tetrachloride, titanium tetrachloride, iron trichloride and aluminum chloride. In formulae (1) and (2), at least one of R¹ and R² is a fluorine-containing hydrocarbon group.;COPYRIGHT: (C)2012,JPO&INPIT