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N displacement 2 amino 4 (hidorokishimechiruhosuhuiniru) manufacturing method null next expression
N displacement 2 amino 4 (hidorokishimechiruhosuhuiniru) manufacturing method null next expression
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机译:N置换2氨基4(hidorokishimechiruhosuhuiniru)制造方法next next expression
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摘要
And a method for efficiently producing a (Z) -N- substituted-2-amino-4-(hydroxymethyl phosphinyl)-2-butene acid derivatives. The following equation (1) [Formula 1] (1) The compound represented by [wherein, R 1 represents a hydrogen atom, a C 1-4 alkyl group in the following formula (2) [Formula 2] (2) The presence or absence of an acid catalyst, a compound represented by [wherein, R 2 represents C 1-4 alkyl, C 1-4 alkoxy group, an aryl group, a benzyloxy group or an aryloxy group] in by the dehydration condensation to, a method of producing a (Z) -N- substituted-2-amino-4-(hydroxymethyl phosphinyl)-2-butene acid derivatives, organic solvent used in the reaction, acetate, toluene, xylene, and a mixed solvent of a solvent selected from the group consisting of chlorobenzene, under capacity 3 to 5 other solvents, the mixing ratio is heated to reflux for 1 volume of acetic acid It is to provide a method to implement by.
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