NUCLEOTIDE AND USE THEREOF FOR MODULATING EXPRESSION OF PROTEIN-KINASE C BETA-1 ISOFORM IN FORM OF SKIN DEPIGMENTATION AGENT

摘要

PROBLEM TO BE SOLVED: To provide a nucleotide for modulating the expression of a protein-kinase C beta-1 isoform.SOLUTION: There are disclosed an oligonucleotide sequence hybridizable with a gene or gene product encoding a protein-kinase C beta-1 isoform (PKC-beta 1) and their derivatives. These can be used as a depigmenting or bleaching agent for the skin in a cosmetic composition or in a topical pharmaceutical composition.