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RNA interference-mediated inhibition of epithelial sodium channel (ENaC) gene expression using short interfering nucleic acids (siNA)
RNA interference-mediated inhibition of epithelial sodium channel (ENaC) gene expression using short interfering nucleic acids (siNA)
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机译:使用短干扰核酸(siNA)的RNA干扰介导的上皮钠通道(ENaC)基因表达抑制
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摘要
The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of ENaC gene expression and/or activity, and/or modulate a ENaC gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against ENaC gene expression.
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