Solid tumor therapeutic agent comprising an expression inhibitor against Wilms tumor gene (WT1)

摘要

PPROBLEM TO BE SOLVED: To provide a novel antitumor agent, i.e. a therapeutic agent for solid tumors comprising an expression-inhibiting substance against Wilms' tumor gene (WT1). PSOLUTION: The therapeutic agent for solid tumors comprises an antisense oligonucleotide derivative against the Wilms' tumor gene (WT1). The antisense oligonucleotide is the one against at least 9 contiguous nucleotides of a transcription capping site of the Wilms' tumor gene. Alternatively, the antisense oligonucleotide is the one against at least 9 contiguous nucleotides of the translation initiation region of the Wilms' tumor gene. Alternatively, the antisense oligonucleotide is the one against at least 9 contiguous nucleotides of an exon of the Wilms' tumor gene. PCOPYRIGHT: (C)2008,JPO&INPIT