MMP-3 blood level lowering agent comprising the IL-6 antagonist as an active ingredient

摘要

PROBLEM TO BE SOLVED: To provide a new determining means for an osteoarthritis therapeutic effect.;SOLUTION: An MMP-3 concentration measuring reagent in a specimen is used for a detecting, evaluating and determining method as (1) an index of for MMP-3 concentration in a specimen, an effect (2) (a) a medicine of an IL-6 antagonist being an active constituent, (b) a cartridge breakage inhibitor of the IL-6 antagonist being an active constituent, or (c) an osteoarthritis therapeutic agent of the IL-6 antagonist being an active constituent; and a cartridge breakage inhibition of a medicine of (1) IL-6 antagonist being an active constituent, or (2) an osteoarthritis therapeutic effect of a medicine of (2) IL-6 antagonist being an active constituent.;COPYRIGHT: (C)2011,JPO&INPIT