Techniques for classifying the amino acid sequence and techniques for predicting the directivity of the HIV virus

摘要

Techniques for categorizing a test sequence are disclosed. An exemplary technique includes defining and utilizing Position Specific Score Matrices that takes into account dependencies of adjacent positions. An embodiment includes predicting HIV viral tropism with improved specificity and sensitivity. Another embodiment includes subdividing a training data set into a set of data subsets, training a plurality of classifiers based on the data subsets, and taking a vote of the plurality of classifiers. Yet another embodiment relates to weighting, in creating a training set, a specified data point based on a distance from the specified data point to an average of the reference plurality of data points.