Isothiourea derivative or isourea derivative having BACE1 inhibitory action

摘要

As a therapeutic agent for diseases induced by production, secretion and / or deposition of amyloid β protein, for example, a compound represented by the following formula (I) and the like are provided. Wherein R1 is substituted amino, R2 is halogen, R3 is substituted or unsubstituted lower alkyl, etc., and RA and RB are each independently hydrogen, substituted or unsubstituted lower alkyl, RC, etc. And RD are each independently hydrogen, substituted or unsubstituted lower alkyl, or the like, or RC and RD together with adjacent carbon atoms form a substituted or unsubstituted carbocycle, and ring A is Or a pharmaceutically acceptable salt or solvate thereof.