Sequence-specific expression regulator targeting MYC downstream gene, and method for determining target or target group of MYC downstream gene

摘要

A pyrrole-imidazole polyamide containing an N-methylpyrrole unit (hereinafter also referred to as Py), an N-methylimidazole unit (hereinafter also referred to as Im), and a γ-aminobutyric acid unit, and having a predetermined base sequence E of MYC downstream gene -A part or all of a BOX region sequence and a predetermined sequence which is an antisense sequence thereof, and further a sequence containing 1-2 base sequences upstream and / or downstream of the E-BOX region and a complementary strand thereto In the minor groove of the double helix region (hereinafter referred to as the target region), it can be folded at the site of the γ-aminobutyric acid unit to take a U-shaped conformation. / Im pairs correspond to Im / Py pairs for GC base pairs, and Py / Py pairs correspond to AT base pairs and TA base pairs, respectively. A drug comprising the pyrrole-imidazole polyamide.