Method for improving specific activity of uricase and modified uricase with improved specific activity

摘要

PPROBLEM TO BE SOLVED: To provide a method for increasing the specific activity of uricase and modified uricase having improved specific activity and to enable the industrial use of the modified uricase. PSOLUTION: The invention relates to a method for increasing the specific activity of a protein having uricase activity by a protein engineering means and modified uricase having specific activity increased by the method. PCOPYRIGHT: (C)2008,JPO&INPIT